Objective To investigate the method and effect of neuroendoscope-assisted keyhole approach in the traumatic frontal epidural hematoma clearance.Methods A total of 60 patients with traumatic frontal epidural hematoma were enrolled (16 with acute epidural hematoma and 44 with subacute epidural hematoma) and underwent frontal or supraorbital keyhole approach, and hematoma was removed under the direct view of a neuroendoscope. The patients' clinical data and surgical outcome were analyzed.Results In all 60 patients, the mean time of operation was 1.1±0.3 hours, the hematoma clearance rate was 89.5%±5.2%, and the mean hospital stay was 6.8 days. At 6 months after surgery, activities of daily living (ADL) were classified for all patients, and among these patients, 45 had class I, 10 had class II, 4 had class III, 1 had class IV, and no patient had class V.Conclusions Neuroendoscope-assisted frontal or supraorbital keyhole approach for frontal epidural hematoma clearance has the advantages of little trauma, a short time of operation, a high hematoma clearance rate, a short hospital stay, and good postoperative recovery, but it is important to strictly select cases and control surgical indications.