Objective To investigate the effects of repetitive transcranial magnetic stimulation on quality of life (QOL) and motor symptoms in patients with depression in Parkinson's disease (dPD).Methods The medical records and follow-up data of 286 dPD patients from February 2011 to January 2015 were analyzed retrospectively, and among these patients, 118 received conventional drug therapy (control group) and 168 received repetitive transcranial magnetic stimulation in addition to the conventional drug therapy (treatment group). The health status survey questionnaire (SF-36 scale) and modified Webster scale were applied to evaluate QOL and motor symptoms in the two groups.Results After treatment, both groups had an improvement in the quality of life (P<0.05). Compared with the control group, the treatment group had significantly higher QOL scores on the subscales of mental health (t=4.44, P<0.01), role-emotional (t=2.47, P=0.01), and energy (t=4.45, P<0.01). The treatment group also had a significantly higher marked response rate for motor symptoms than the treatment group (χ²=4.73, P<0.05).Objective Repetitive transcranial magnetic stimulation can significantly improve the QOL in dPD patients, and has better effects in the aspects of mentality, emotion, and energy. In addition, it can also improve motor symptoms in dPD patients.