Objective To investigate the function of neurotransmitters in patients with mental disorders induced by alcoholism using the encephalofluctuograph (EFG), and to explore the pathogenesis of mental disorders induced by alcoholism.Methods The patients who met the diagnostic criteria for mental disorders induced by alcoholism in Chinese Classification of Mental Disorders (3rd version) (CCMD-3) were enrolled as the study group, and healthy subjects were enrolled as the normal control group. EFG examination was performed for both groups and the results were compared between the two groups.Results Compared with the normal control group, the study group had significantly decreased powers of 9 neurotransmitters (P<0.05), as well as a significantly decreased relative power of norepinephrine (NE) (P<0.05); compared with the normal control group, the study group also had significantly reduced total brain power, motor index, and vasomotor index (P<0.05).Conclusions The powers of neurotransmitters decline in patients with mental diseases induced by alcoholism, especially the decreased power of NE. Such patients may also have vasomotor dysfunction. EFG can analyze the function of neurotransmitters and blood supply in brain neural cells and helps the research on the pathogenesis of mental diseases induced by alcoholism.