Objective To investigate and analyze the effect of early enteral nutrition support on nutritional status, immune function, and prognosis in patients with severe cerebrovascular disease (SCVD).Methods Fifty-six patients with SCVD who were treated in our hospital were selected as research subjects and were divided into control group (parenteral nutrition support) and research group (early enteral nutrition support) according to the nursing methods, with 28 patients in each group. The nutritional status, immune function, and prognosis of the two groups were compared on the day of admission and after nutritional support for 10 days.Results After the nutritional support for 10 days, compared with the control group, the research group had significantly higher serum levels of total protein, triglyceride, alanine aminotransferase, and blood glucose, as well as significantly higher levels of IgG, IgA, and CD4/CD8, and a significantly lower total lymphocyte count (P<0.05). Compared with the control group, the research group had significantly higher Activities of Daily Living score and Fugl-Meyer motor function score and a significantly lower National Institutes of Health Stroke Scale score (P<0.05).Conclusions In patients with SCVD, early enteral nutrition support can provide necessary nutritional support, improve the health status, regulate disorders, enhance immunity, and improve patient outcome and quality of life, and, therefore, it is worthy of clinical promotion and application.