Objective To clarify the effects of surgical treatment of intracranial cavernous angioma with epilepsy in children.Methods The clinical data of 27 children with intracranial cavernous angioma and epilepsy who underwent surgery in our hospital from February 2010 to May 2014 were analyzed retrospectively. The clinical characteristics of intracranial cavernous angioma in these children were analyzed. The remission of epilepsy was followed up for these children after surgery and evaluated by Engle's classification. Surgical effects and prognosis were analyzed.Results All patients underwent surgical resection. After surgery, 1 patient experienced contralateral hemiplegia after resection of cavernous angioma in the basal ganglia and from the time after treatment to follow-up visit, this patient's neurological function had been restored to the preoperative status. One patient experienced intracranial infection after surgery, and was improved and discharged after treatment. The remission of epilepsy after surgery was good, with 25 cases of Engle's class I, 1 case of Engle's class Ⅱ, and 1 case of Engle's class Ⅲ. No death or severe complication occurred.Conclusions The surgical treatment is an effective way to handle intracranial cavernous angioma with epilepsy, and can prevent recurrence of hemorrhage related to cavernous angioma and improve prognosis. Patients with multiple cavernous angioma lesions and long-term epilepsy should be fully evaluated before surgery.