Objective To investigate the effects of developing targeted rehabilitation plan according to Brunnstrom stage on the rehabilitation of patients with stroke.Methods Ninety patients with stroke were selected and randomly divided into experimental group and control group according to the random number table, with 45 cases in each group. The rehabilitation plan for the experimental group was developed according to Brunnstrom stage and the control group received routine rehabilitation treatment.Results Before rehabilitation treatment, the scores of Fugl-Meyer Assessment Scale (FMA), modified Barthel Index (MBI), Motor Assessment Scale (MAS), National Institutes of Health Stroke Scale (NIHSS), and Stroke-Specific Quality of Life (SS-QOL) did not differ significantly between the experimental group and the control group (P>0.05). After rehabilitation treatment, the FMA score (48.2±7.6), MBI score (58.2±11.6), MAS score (33.7±6.2) and SS-QOL score (44.8±5.3) in the experimental group were significantly higher than those in the control group (29.6±5.7, 53.6±9.8, 29.6±5.7, and 40.2±5.0, respectively) (P<0.05). The NIHSS score in the experimental group (13.5±3.8) was significantly lower than that in the control group (15.7±4.0) (P<0.05).Conclusions Compared with routine rehabilitation treatment, developing targeted rehabilitation plan according to Brunnstrom stage has better effects on the rehabilitation of patients with stroke and can improve the patients' quality of life.