Abstract:Objective To investigate the factors related to postoperative hydrocephalus in patients with severe traumatic brain injury (sTBI).Methods A total of 281 sTBI patients who were admitted to our hospital from March 2006 to July 2013 were divided into hydrocephalus group (n=45) and non-hydrocephalus group (n=236). Univariate and multivariate logistic regression was used to analyze the factors including location of intracranial hematoma, duration of operation, open craniocerebral injury, subarachnoid hemorrhage (SAH), decompressive craniectomy, dura mater opening, and lumbar puncture cerebrospinal fluid (CSF) replacement.Results The univariate logistic regression analysis showed that there were significant differences in intracranial hematoma location, open craniocerebral injury, SAH, decompressive craniectomy, dura mater opening, and lumbar puncture CSF replacement between the two groups (P<0.05). The multivariate logistic regression analysis showed that there were also significant differences in above indices between the two groups (P<0.05). The risk factors for postoperative hydrocephalus were open craniocerebral injury, SAH, subdural hematoma, intracranial hematoma, decompressive craniectomy, and dura mater opening, and the lumbar puncture CSF replacement was a protective factor for postoperative hydrocephalus.Conclusions Open craniocerebral injury, subdural hematoma, intracranial hematoma, SAH, decompressive craniectomy, and dura mater opening are the risk factors for postoperative hydrocephalus, and lumbar puncture CSF replacement is the protective factor for postoperative hydrocephalus.