Objective To investigate the clinical efficacy of rehabilitation training combined with hyperbaric oxygen therapy in the treatment of flaccid paralysis caused by hand, foot and mouth disease.Methods Seventy children with flaccid paralysis caused by hand, foot and mouth disease were randomly divided into treatment group (n=35) and control group (n=35). The control group was given conventional treatment including isolation, anti-infection, nutritional support, brain protection, and acupoint injection of mouse nerve growth factor, while the treatment group was given additional rehabilitation training and hyperbaric oxygen therapy based on the conventional treatment. The efficacy of the two groups was evaluated by manual muscle strength test, activities of daily living and Fugl-Meyer assessment (FMA).Results Compared with the control group, the treatment group had significantly better recovery of muscle strength and significantly higher BI index and FMA score (P<0.05). Conclusions Rehabilitation training combined with hyperbaric oxygen therapy in the treatment of flaccid paralysis caused by hand, foot and mouth disease can significantly increase the muscle strength of the paralyzed limb, increase BI index and FMA score, reduce the probability of paralysis and disability, and improve the activities of daily living for the children. Its overall efficacy is better than conventional treatment.