Objective To investigate the clinical effect of different doses of atorvastatin in the treatment of acute ischemic stroke.Methods One hundred and twenty-five cases of acute ischemic stroke were divided into three groups randomly. Group A received atorvastatin 10 mg/d, group B received atorvastatin 20 mg/d, and group C did not receive any lipid-lowering drugs. The blood levels of lipids, inflammatory cytokines, and fibrinogen (FIB), neurological impairment status, and viability before and after treatment were evaluated among the three groups.Results The decreases in levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in group B were significantly higher than those in group A (P<0.05). The decreases in levels of inflammatory cytokines and increases in scores of Activities of Daily Living and National Institute of Health Stroke Scale in groups A and B were significantly higher than those in group C (P<0.01). The decreases in levels of inflammatory cytokines and FIB in group B were significantly higher than those in group A (P<0.05).Conclusions For patients with acute ischemic stroke, atorvastatin 20 mg/d, compared with atorvastatin 10 mg/d, can lower lipid levels and reduce inflammation more effectively, so as to stabilize atherosclerotic plaques, restore the nervous system function, and improve the quality of life with higher safety.