Objective To investigate the risk factors for early deep venous thrombosis (DVT) of the lower extremities in stroke patients.Methods A total of 144 inpatients within 48 hrs of stroke onset were included in the study. D-dimer (DD), fibrinogen (Fib), and C-reactive protein (CRP) levels were measured within 24 hrs after admission. Venous duplex ultrasound of the bilateral lower extremities was performed on the 3rd day and 14th day after stroke to calculate the incidence of early DVT of the lower extremities. The data of stroke patients with early DVT were compared with those of stroke patients without DVT to identify the risk factors for DVT of the lower extremities after stroke.Results The incidence of early DVT in stroke patients was 6.3%. Logistic regression analysis indicated that moderate or severe stroke and elevated CRP and Fib levels were independent risk factors for early DVT in stroke patients.Conclusions Stroke patients are the high-risk population for DVT. Surveillance and prophylaxis of DVT are necessary in severe stroke patients with elevated CRP and Fib levels.