Objective To study the incidence of neuroendocrine hormone abnormalities and its clinical significance in the recovery phase of brain injury.Methods Patients with brain injury were included in this study. The concentrations of FT3, FT4, TSH, ACTH, GH, Cor, PRL, T, E2, P, FSH, and LH in the peripheral venous blood were measured by radioimmunoassay at 3, 6, and 12 months after brain injury. Statistical analysis was performed to determine the incidence of neuroendocrine hormone abnormalities in the recovery phase of brain injury and its relationship with the disease severity and recovery time.Results The incidence of neuroendocrine hormone abnormalities was positively correlated with the severity of brain injury (P<0.05). The incidence of neuroendocrine hormone abnormalities was 17.6%, 16.2%, and 15.4% at 3, 6, and 12 months, respectively, after brain injury; the incidence gradually decreased with time, but without significant differences between the values at the three time points (P>0.05).Conclusions In the recovery phase of brain injury, neuroendocrine hormone abnormalities may occur. The severer the brain injury, the higher the incidence of neuroendocrine hormone abnormalities; the incidence of neuroendocrine hormone abnormalities gradually decreases with time. Neuroendocrine hormone levels can be used as an important index to guide clinical therapy.