Objective To investigate the influential factors for abstinence adherence in patients with alcohol dependence after stroke.Methods A total of 134 patients with alcohol dependence were selected from the multi-center stroke registry database in Changde, China to investigate their alcohol uses one year after stroke. These patients were grouped according to educational level, location of stroke lesion, and so on. Statistical analysis of data was performed using SPSS 20.0 to determine the influential factors for abstinence adherence.Results Of all patients, 56.7% abstained from drinking. Compared with the abstinence group, the relapse group had a significantly higher proportion of individuals who divorced, were bereft of their spouses, or remarried (18/40 vs 9/67, χ²=7.531,P=0.006), a significantly higher proportion of individuals who lived in rural areas (33/25 vs 7/49, χ²=6.067,P=0.014), significantly higher daily alcohol consumption (510±187 ml vs 392±101 ml,t=3.93,P=0.000), and a significantly higher HRSD-24 score (19±6.1 ml vs 10±7.3 ml,t=4.37,P=0.000). The abstinence rates for patients with educational levels of primary school and below, secondary school, and college and above were 46.2%, 63.4%, and 73.1%, respectively, with a significant difference between the three groups (χ²=6.563,P=0.038). The logistic regression analysis showed that less education, depression after stroke, and lesion in the frontal lobe were adverse factors for abstinence adherence (OR=1.292, 7.217, and 2.282, respectively).Conclusions Poor marriage, living in rural areas, high daily alcohol consumption, low education level, depression after stroke, and frontal lobe stroke are adverse factors for abstinence adherence. Medical workers should strengthen psychological counseling and health guidance, and alcohol consumption should be controlled at home after discharge.