目的 探讨小儿癫痫发作类型、脑电图异常、手术效果等与癫痫患儿脑FDG-PET显像的相关性。方法 方法回顾经临床、脑电图、影像学检查确诊的并行手术治疗的71例癫痫患儿脑18F-FDG-PET显像检测结果，以了解癫痫灶脑细胞葡萄糖代谢情况。根据脑FDG-PET显像结果，将71例患儿分为3个代谢减低组。33例患儿脑代谢减低位于单个脑叶，28例位于两个脑叶，10例多个脑叶均见代谢减低。收集71例患儿病程、性别、年龄、发作类型、脑电图资料、手术效果等临床资料，采用卡方检验，统计分析3个代谢减低组之间临床资料的总构成比差别。结果 癫痫发作类型、癫痫放电异常程度和术后效果在脑代谢减低3组间均有明显的区别，差异有统计学意义（P<0.05）。结论 脑FDG-PET显像与手术效果、发作类型和脑电图异常均明显相关。
Objective To investigate the correlation of brain fluorodeoxyglucose (FDG) positron emission computed tomography (PET) findings with seizure type, electroencephalography (EEG) abnormality, and surgical outcome in children with epilepsy. Methods A retrospective study was conducted on the brain 18F-FDG PET findings of 71 children, who were diagnosed with epilepsy by clinical examination, EEG, and imaging examination and received surgical treatment, to investigate the glucose metabolism in brain cells in the epileptic focus. According to the PET findings, the 71 patients were divided into three hypometabolism groups, including 33 cases with hypometabolism in a single lobe, 28 cases with hypometabolism in two lobes, and 10 cases with hypometabolism in more than two lobes. The clinical data of the 71 patients, such as course of disease, sex, age, seizure type, EEG data, and surgical outcome, were collected. The chi-square test was used for comparing the three groups in terms of the constituent ratios in each item of the clinical data. Results No significant differences in age and sex were seen between the three hypometabolism groups, but there were significant differences in seizure type, EEG abnormality, and surgical outcome between them (P<0.05). Conclusions Brain FDG PET findings are significantly correlated with surgical outcome, seizure type, and EEG abnormality in children with epilepsy.
夏桂枝, 任榕娜, 杨朋范, 郑思锐.癫痫患儿脑FDG-PET显像与发作类型、脑电图异常及手术效果的相关性[J].国际神经病学神经外科学杂志,2013,40(3):212-215复制