白细胞介素-1B多态性与神经胶质瘤的关联
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Association between interleukin-1B polymorphisms and risk of glioma
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    摘要:

    目的 探讨白细胞介素-1B(IL-1B)多态性与神经胶质瘤的相关性。方法 采用聚合酶链反应-限制性片段长度多态性检测152例神经胶质瘤患者和201例正常对照组IL-1B-511C/T和-31T/C多态性。结果 IL-1B-511C/T位点:与CC基因型相比,TT基因型显著增加了神经胶质瘤的发病风险(χ 2=5.61,P=0.021)。与C等位基因相比,T等位基因显著增加了神经胶质瘤的发病风险(χ2=5.71,P=0.019)。未发现IL-1B-31T/C多态性频率分布在对照组和神经胶质瘤组之间存在明显差异。IL-1B-511C/T和-31T/C两位点单倍型分析显示,-511C/-31T单倍型显著降低了神经胶质瘤的发病风险(χ2=4.89,P=0.03),-511T/-31C单倍型显著增加了神经胶质瘤的发病风险(χ2=18.55,P<0.001)。结论 IL-1B可能是中国人群神经胶质瘤发病的易感基因。

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    Objective To investigate the association between interleukin-1B (IL-1B) polymorphisms and risk of glioma. Methods The IL-1B-511C/T and-31T/C polymorphisms were detected in 152 patients with glioma and 201 healthy controls using polymerase chain reaction-restriction fragment length polymorphism analysis. Results The TT genotype at position-511C/T in the promoter region of IL-1B was associated with a significantly increased risk of glioma compared with the CC genotype (χ2=5.61, P=0.021). Similarly, the Tallele at position-511C/T was associated with a significantly increased risk of glioma compared with the Callele (χ2=5.71, P=0.019). There was no significant difference in the frequency distribution of IL-1B-31T/C polymorphism between cases and controls. Results from haplotype analysis showed that the -511C/-31T haplotype was associated with a significantly decreased risk of glioma (χ2=4.89, P=0.03); conversely, the -511T/-31C haplotype was associated with a significantly increased risk of glioma (χ2=18.55, P<0.001). Conclusions IL-1B may be a susceptibility gene for the development of glioma in Chinese population.

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岩亮, 舒云.白细胞介素-1B多态性与神经胶质瘤的关联[J].国际神经病学神经外科学杂志,2013,40(3):204-207

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  • 收稿日期:2013-03-30
  • 最后修改日期:2013-06-18
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  • 在线发布日期: 2013-06-28
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