Objective To evaluate the clinicopathologic and neuroimaging findings of GC and to compare the clinical findings between Type 1 and Type 2 GC.Methods Clinical comparison between subtypes and clinical analysis were performed.Results The clinical manifestions of these 13 patients included headache (8/13) and seizure (3/13).Radiological examination revealed diffuse lesions infiltative process involving more than three cerebral lobes,a diagnosis of MRS should be considered. Histologically, 13 cases of GC were classified into low and high grade histologic grades by cytologic anaplasia. Low-grade GC was more common in Type 1 than Type 2.Immunohistochemical and Ultramicrostructure Results demonstrated that the infiltrating tumor cells were undifferentiated cells with astrocytic or oligodendroglial differentiation.Conclusions Type 1 and 2 GC are somewhat different in neuroimaging and pathologic features. Type 1 GC were undifferentiated cells with astrocytic common. Treatment of GC was based on magnetic resonance imaging findings and histological confirmation for patients.