Objective To explore the clinical manifestations, EEG findings, diagnosis, therapy and prognosis of West syndrome.Methods The clinical data of 32 children with West syndrome were retrospectively studied.Results Of the 32 patients, there were 23 boys and 9 girls, and aged from 5 months to 3 years old. The classic triad (entasia, developental regression and hypasarrhythmia) was seen in 28 children. All children's EEG results were abnormal (classic hypasarrhythmia in 24 cases and atypical hypasarrhythmia in 8 cases). Four children were treated with ACTH and antiepileptic drugs (AEDs). After treatment, 2 children became spasm-free, 1 had more than 50% spasm reduction, and 1 did not respond to the treatment. The other 28 children were treated only with AEDs, and of them 17 became spasm-free, 6 had more than 50% spasm-free, 5 did not respond to the treatment. 16 cases were followed up for 2 months, and 11 cases of them were spasm-free, 3 cases showed less than 50% erduction and 2 did not respond to the treatment.Conclusions West syndrome is a special epileptic syndrome in the infantile period, and the onset is in the intelligence development period. The patients usually have brain damage sequelae. In addition to typital attacks and spiritual movement disorders, there are specific EEG changes in these patients.