Objective To study the prevalence of depression at 2 weeks and 3 months after stroke and relevant factors of post stoke depression.Methods Two hundreds and fifty-seven patients with acute stroke were prospectively followed at 2 weeks and 3 months after stroke.Results Depressive rate 2 weeks after stroke was 32.59%, with a minor depression rate of 20.92%, and a major depression rate of 11.67%. Post stroke depression rate was 42.68% 3 months after stroke, including minor depression of 19.87% and major depression of 22.81%. Independent relevant factors for post stroke depression 2 weeks after stroke included introversion personality (P=0.000), diabetes (P=0.000), and severe neurologic impairment (P=0.000). Independent relevant factors for post stroke depression 3 months after stroke included depression diagnosed at the acute stage (P=0.000) and anterior circulation stroke (P=0.04).Conclusions Depression rate after stroke is high. Depression at 2 weeks after stroke is associated with introversion personality, severe neurologic impairment and diabetes. The independent relevant factors for depression at 3 months after stroke are depression diagnosed at the acute stage and anterior circulation stroke.