Objective To explore the curative effect of microsurgical removal tumors in the sella region via frontolateral keyhole approach.Methods Clinical data of 39 cases of sella region tumors operated by frontolateral keyhole approach and it's advantage and disadvantage compared with usual craniotomy operation were described.Results Among 15 cases of pituitary adenomas,the tumor was totally removed in 11 cases (73.3 percent)and subtotally removed in 2 cases and partially removed in 1 cases. Besides 3 cases of craniopharyngioma were subtotal removal,7 cases (70 percent)of craniopharygioma were totally removaed. The tumor of meningiomas were totally removed in all 14 cases(100 percent). Among 39 cases of sella region tumors,18 cases had different degree of insipidus and electrolyte disturbance, those conditions were improved by the drug treatment, the visual acuity of 23 cases was improved. Good recovery after operation was achieved in 39 cases.Conclusions The frontolateral keyhole approach could provide sufficient operating space in the sella region. The operative treatment of sellar region tumors by frontolateral keyhole approach may be practicable and safe. It's advantage is minimal invasive and little blood infusion and rapid recovery and so on.