Objective To investigate the association between two single nucleotide polymorphisms, rs6723097 and rs13113, of apoptosis regulatory gene CASP8 and the susceptibility to meningioma in Chinese population.Methods The study was designed as a case-control study. 205 meningioma patients and 195 healthy controls were collected. The SNPs(including rs6723097 and rs13113) of CASP8 gene were analyzed by Multiplex SNaPshot methods. The distributions of genotype frequencies and allele frequencies were calculated and compared in the meningioma group and control group. The relationship between different genotypes of the two SNPs(including rs6723097 and rs13113) and the clinical phenotypes of meningioma was analyzed.Results The genotype frequencies of GG,GT,TT of CASP8 rs6723097 were 23.4%, 47.3%, 29.3% in meningioma group and 22.6%, 51.3%, 26.2% in control group. The genotype frequencies of AA,AT,TT of CASP8 rs13113 were 22.0%,49.8%,28.3% in meningioma group and 24.1%,51.3%,24.6% in control group. No significant associations were found between these two polymorphisms and meningioma. Pairwise Linkage disequilibrium analyses showed that the polymorphic loci between rs6723097 and rs13113 were in strong Linkage disequilibrium(D'=0.901).The SNPs(including rs6723097 and rs13113) of CASP8 gene showed no difference of genotype distribution in different clinical phenotypes of meningioma.Conclusions The genetic variation of CASP8 rs6723097 and rs13113 may not play an important role in the susceptibility of meningioma in Chinese population.