Objective To explore the relationship of the chemokine receptor CCR2b gene 190G/A polymorphism with intracerebral hemorrhage (ICH) in Han population in Hunan Province.Methods For the case-control study, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to identify the distributions of allele and genotype frequencies of the chemokine receptor CCR2b gene 190G/A polymorphism in 158 patients with ICH and 150 age-and sex-matched healthy controls. Genotypes of different populations were compared to explore the association between the chemokine receptor CCR2b gene 190G/A polymorphism and ICH.Results Chemokine receptor CCR2b gene 190G/A polymorphism existed in Chinese Han people of the Hunan area. In the study population, the frequencies of the chemokine receptor CCR2b 190G/A genotypes were 3.6% (AA), 22.1% (GA) and 74.3% (GG) respectively, and the frequencies of allele A and G were 0.146 and 0.854 respectively. In the control group, the frequencies of the chemokine receptor CCR2b 190G/A genotypes were 5.3% (AA), 28.0% (GA) and 66.7% (GG) respectively, and the frequencies of allele A and G were 0.193 and 0.807 respectively. In the ICH group, the frequencies of the chemokine receptor CCR2b 190G/A genotypes were 1.9% (AA), 16.5% (GA) and 81.6% (GG) respectively, and the frequencies of allele A and G were 0.102 and 0.898 respectively. To the chemokine receptor CCR2b gene 190G/A polymorphism, a significantly lower frequency of A allele was confirmed in the ICH group compared with the control group (P<0.05), especially in patients with hypertention and coronary heart disease. After environmental risk factors for ICH had been adjusted through Logistic regression method, the CCR2b 190A allele was still related to a lower incidence of ICH (OR=0.205, 95%CI: 0.092-0.454, P=0.000).Conclusions CCR2b 190A allele may be a protective gene polymorphism for ICH in Han population of the Hunan area.