Objective To study the risk factors for the development of progressive ischemic stroke (PIS).Methods The clinical data of 524 cases of ischemic stroke were analyzed retrospectively.The patients were classified into progress and non-progress groups.The risk factors for the development of PIS were evaluated by logistic regression method.Results The single-factor analysis showed that the diabetes, hypertension history, and carotid atherosclerosis, and the levels of blood glucose at admisson, NIHSSS score and fibrinogen in the progress group were significantly higher than in the non-progress group.Multivariate logistic regression analysis showed that diabetes, high blood glucose level at admission and carotid atherosclerosis were the risk factors of PIS (OR=3.796, 1.251 and 3.883 respectively;P<0.05).Conclusions Diabetes, high blood glucose level at admission and carotid atherosclerosis are risk factors for the development of PIS.