Objective To study the digital subtraction angiography (DSA) images in patients with cerebral watershed infarction (CWI) and the risk factors of the development of CWI.Methods The DSA image Results of 64 patients with CWI confirmed by MRI were retrospectively studied. The risk factors of CWI were evaluated by univariate analysis and multivariate logistic regression analysis.Results Of the 64 patients, 27 showed cerebrovascular stenosis, 15 showed cerebrovascular dolichoectasia, and 6 showed cerebrovascular stenosis and cerebrovascular dolichoectasia. Multivariate logistic regression analysis showed age (elder), hypertension, male, smoking, and increased trough/peak ratio were the independent risk factors for CWI.Conclusions Most of CWI patients present with cerebrovascular disorders by DSA. Targeted prevention and treatment by controlling risk factors, age (elder), hypertension, male, smoking and increased trough/peak ratio, may be important to reduce the occurrence of CWI.