Objective To study the clinical efficacy of punctures and drainage of hematoma through frontal region and drainage from contralateral lateral ventricle for treatment of severe intracerebral hemorrhage in the basal ganglion ruptured into the cerebral ventricles.Methods Punctures and drainage of hematoma through frontal region and drainage from contralateral lateral ventricle was performed in 18 patients (minimally invasive group) with severe intracerebral hemorrhage in the basal ganglion ruptured into the cerebral ventricles and only medical treatment was used in 20 matched cases (medical treatment group) with the same disease for control.Results The total effective rate (77.8%) and the Barthel Indexes (62.34±22.15) in the minimally invasive group were significantly higher than those in the medical treatment group (P<0.05). In addition, the incidences of cerebral herniation (11.1%), electrolyte disturbances (16.7%) and pulmonary infection (22.2%) in the minimally invasive group were significantly lower than those in the medical treatment group (P<0.05).Conclusions Punctures and drainage of hematoma through frontal region and drainage from contralateral lateral ventricle can be a safe and effective method for treatment of severe intracerebral hemorrhage in the basal ganglion ruptured into the cerebral ventricles.