Objective To investigate the relationship between A566G (Asn166Asp) polymorphism in the exon 6 of p47^phox gene and cerebral hemorrhage in the Han people in Changsha of Hunan Province.Methods A566G (Asn166Asp) polymorphism in p47^phox gene was determined by PCR-single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 110 patients with cerebral hemorrhage and 10 cerebral hemorrhage pedigrees from Han population in Changsha of Hunan Province. Plasma lipid levels were measured by routine methods.Results No statistically significant differences were found in the frequencies of genotypes and alleles of A566G (Asn166Asp) polymorphism between the cerebral hemorrhage patients and the controls and between cerebral hemorrhage pedigrees and the controls. There were no statistically significant differences in the plasma lipid levels between the cerebral hemorrhage patients and the controls (P>0.05).Conclusions There seems no correlation between A566G (Asn166Asp) polymorphism and cerebral hemorrhage in Han people in Changsha of Hunan Province.