Objective To report the minimally invasive surgical treatment of focal cortical dysplasia (FCD)-associated refractory epilepsy by neuronavigation combined with intraoperative electrocorticogram (ECoG).Methods 26 patients with FCD epilepsy were routinely examined by CT, magnetic resonance imaging (MRI), vedio-electrocorticogram (VEEG), MR spectroscopy (MRS), etc preoperatively. Patients were undergone functional magnetic resonance imaging (fMRI) if epileptogenic focus located in the eloquent areas. During surgery, compared the results of neuronavigation and ECoG to learn the consistency between them, comprehensively analyzed of the accurate origin of epileptic wave, the location and extent of epileptogenic focus, resected the FCD lesions and surrounding epileptogenic cortex. Patients underwent lower power electrocoagulation if epileptogenic focus located in the eloquent areas, the eloquent cortex was carefully protected meanwhile.Results FCD was found in postoperative pathological examination in all the 26 cases. According to Engel classification system, 23 case of Class Ⅰ, 2 case of Class Ⅱ, 1 case of Class Ⅲ, and the total cure rate was 88.5%.Conclusions Neuronavigation combined with ECoG for FCD associated refractory epilepsy surgery has the following advantages: accurate localization, less damage. removal of epileptic foci while protecting brain function to the greatest degree.