Objective:To investigate the cognitive function in middle-aged women with migraine.Methods: One hundred and eight patients with migraine(50 males,58 females) were enrolled.In the 50 male patients,there were 15 cases of migraine with aura and 35 cases without aura.In the 58 females(48.74±6.61 years old),there were 15 cases of migraine with aura and 43 cases without aura.Montreal Cognitive Assessment Beijing Version was used to assess the cognitive abilities:visual-spatial concepts,naming,memory,attention,verbal fluency,abstraction,delayed word recall and orientation.Results: The cognitive abilities in visual-spatial concepts,delayed word recall and abstraction in female migraine patients with aura were significantly lower than in those without aura.The total cognitive ability in female migraine patients was significantly lower than that in male migraine patients.The abstraction ability and the total cognitive ability in female migraine patients with aura decreased significantly compared with those in male migraine patients with aura.Conclusions: Migraine affects cognitive function in middle-age women.The abstraction ability is remarkably reduced in female migraine patients with aura.