Objective To study the difference of high-sensitivity C-reactive protein (hsCRP) between male and female in first-episode acute cerebral ischemic stroke patients and healthy people.Methods A total of 138 patients with first-episode acute ischemic stroke and 150 healthy controls were enrolled.The cases were well-matched to the controls for age and sex.Peripheral blood samples from stroke patients were obtained 72 hours after stroke.The samples from controls were obtained in the morning.Serum levels of hsCRP were determined.Results The mean levels of plasma hsCRP were significantly higher in stroke patients than controls(P<0.05).There were statistical differences in plasma hsCRP levels between healthy men and women (P<0.05), and between stroke women and healthy women (P<0.05), but no statistical differences were found betweens stroke men and women (P>0.05), and between stroke men and healthy men (P>0.05).Conclusions There are gender differences in serum hsCRP levels.The inflammatory response may be associated more closely with cerebral ischemic events in women than in men.